N. Tran

An Evaluation of the Efficacy of Single-Echo and Multi-Echo fMRI Denoising Strategies

This study evaluates denoising strategies for resting-state fMRI, finding that multi-echo pipelines generally outperform single-echo ones but no single method is optimal for all tasks.

Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma

This paper develops BioNet, a biologically-informed deep learning model, to predict intratumoral heterogeneity in post-treatment glioblastoma using MRI and biopsy data, showing improved performance over existing methods.

Unravelling the Impact of miR-21 Overexpression on the MicroRNA Network and Cancer Pathways

This study investigates how miR-21 overexpression affects miRNA networks and cancer-related pathways by identifying miR-17-92a as a potential target and showing shifts in miRNA expression.

Widespread prevalence of a post-translational modification in activation of an essential bacterial DNA damage response

The paper identifies a conserved bacterial transcription factor, Cada2, that mediates a methylation-dependent DNA damage response distinct from the SOS response.

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

This study identifies monocarboxylate transporters (MCTs) as facilitators of succinate uptake into brown adipocytes, showing their role in metabolic disease protection.

The H163A Mutation Unravels an Oxidized Conformation of the SARS-CoV-2 Main Protease and Opens a New Avenue for Anti-Viral Therapeutic Design

This study identifies an oxidized conformation of SARS-CoV-2 Mpro through a point mutation and suggests it could inform new antiviral strategies.

Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome

This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

The paper develops a workflow for collecting and analyzing liver immune cells via fine-needle aspirates and single-cell RNA sequencing to better understand tissue-specific immunity in chronic hepatitis B.

Misregulation of MYB16 causes stomatal cluster formation by disrupting polarity in asymmetric cell division

This study shows that MYB16 misregulation disrupts polarity in asymmetric cell division, leading to stomatal clustering in plants.

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in Pigs

This study examines microglial morphology and axonal pathology in pigs with mild TBI over one year, finding persistent microglial morphological changes but no astrocyte reactivity or corpus callosum changes.

Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics

This study uses single-cell transcriptomics and protein profiling to analyze EBOV infection in rhesus monkeys, revealing changes in immune cell dynamics and viral/host gene expression.

Genomic potential for photoferrotrophy in a seasonally anoxic Boreal Shield lake

This study identifies photoferrotrophic potential in Boreal Shield lakes using genome-resolved metagenomics and enrichment cultivation, revealing ecological and biogeochemical controls on this process.