Author

D. Kuppers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. PADDISON· 3 shared S. Arora· 2 shared A. Hsieh· 1 shared A. Lim· 1 shared A. Rongvaux· 1 shared B. Torok-Storb· 1 shared C. Plasier· 1 shared E. Girard· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

P. PADDISON

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional genomic analysis of adult and pediatric brain tumor isolates

P. Hoellerbauer, M. Biery, S. Arora, Y. Rao, E. Girard, K. Mitchell, P. Dighe, M. Kufeld, D. Kuppers, J. Herman, E. Holland, L. Soroceanu, N. Vitanza, J. Olson, J. Pritchard, P. PADDISON

This study identifies shared and unique gene dependencies between adult and pediatric brain tumor isolates using CRISPR screens and machine learning models.

bioRxiv · Jan 5, 2023 · PreprintCancer Biology

Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

D. Kuppers, J. Linton, S. Ortiz, K. McKenna, A. Rongvaux, P. PADDISON

The paper develops a method to efficiently edit human CD34+ HSPCs before transplantation, enabling gene knock-outs in the human immune system of mice with high efficiency and without affecting engraftment potential.

bioRxiv · Oct 6, 2022Bioengineering

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

D. Kuppers, S. Arora, Y. Lim, A. Lim, L. Carter, P. Corrin, C. Plasier, R. Basom, J. Delrow, S. Wang, H. He, B. Torok-Storb, A. Hsieh, P. Paddison

The paper identifies m6A mRNA methylation as a regulator of erythropoiesis by promoting the translation of key genes involved in erythroid lineage specification.

bioRxiv · Oct 31, 2018Cell Biology