E. Girard

The nucleating agent crystallophore induces instant protein crystallization

This paper demonstrates how the crystallophore TbXo4 accelerates protein crystallization, enabling high-quality crystals for serial crystallography methods.

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

This study shows that blocking CSF-1R in tumor-associated macrophages alters their metabolism, enhancing sensitivity to 5-fluorouracil in colorectal cancer.

Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy

This study identifies BRG1 inhibition as a therapeutic strategy for CBFA2T3-GLIS2 AML by analyzing chromatin profiles and CRISPR dependencies.

Functional genomic analysis of adult and pediatric brain tumor isolates

This study identifies shared and unique gene dependencies between adult and pediatric brain tumor isolates using CRISPR screens and machine learning models.

FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation, and lethality in glioblastoma and other cancers

This study identifies FBXO42 as essential for preventing mitotic arrest and cell death in glioblastoma and other cancers by suppressing chromosome-microtubule dynamics disruption.

Experimental investigations of the human oesophagus: anisotropic properties of the muscular layer in large deformation

This study investigates the anisotropic mechanical properties of the human oesophagus muscular layer under large deformation, showing directional differences in stiffness and strain-rate dependency.

Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin

This paper identifies ASGR1 as a novel PCSK9-independent ligand of liver LDLR that is shed by Furin, leading to reduced LDLR levels and LDL uptake.

Textile waste and microplastic induce activity and development of unique hydrocarbon-degrading marine bacterial communities

The paper investigates how marine microbial communities respond metabolically to textile waste and microplastics, showing increased activity of hydrocarbon-degrading bacteria.

Tracking crystallophore nucleating properties: setting-up a database for statistical analysis.

The paper introduces a database to analyze the nucleating properties of Crystallophore proteins and compares Tb-Xo4 with Lu-Xo4 for improved phasing.

Monitoring the production of high diffraction-quality crystals of two enzymes in real time using in situ dynamic light scattering

This paper describes the use of in situ dynamic light scattering to monitor and control crystallization of two enzymes, achieving high-quality crystals for structural studies.

Muscle MACF1 maintains myonuclei and mitochondria localization through microtubules to control muscle functionalities

This study identifies MACF1 as a regulator of myonuclei and mitochondria positioning in muscle through microtubules, affecting muscle function and disease.

Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli

The paper quantifies epistasis across 2,382 E. coli genes using orthologs and finds stronger epistasis in highly expressed genes, explained by protein unfolding models.