Central tolerance is impaired in the middle-aged thymic environment
J. N. Lancaster, D. L. Keatinge-Clay, J. Srinivasan, Y. Li, H. J. Selden, S. Nam, E. R. Richie, L. I. R. Ehrlich
This study shows that the middle-aged thymic environment impairs central tolerance by reducing mTECs and antigen-presenting cells, leading to less efficient negative selection and Treg induction.
bioRxiv · Jan 17, 2022Immunology