Author

H. J. Selden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Srinivasan· 4 shared L. I. R. Ehrlich· 4 shared E. R. Richie· 2 shared Y. Li· 2 shared A. Calindi· 1 shared A. Krueger· 1 shared A. Vasudev· 1 shared B. J. LaFleur· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

J. Srinivasan

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4 papers

Recent·Most cited

Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk

J. Srinivasan, C. R. Moore, A. Calindi, B. R. Helm, Y. Yang, J. F. Moore, H. J. Selden, C. N. Heiser, Q. Liu, K. Lau, L. I. R. Ehrlich

The paper identifies seven thymic conventional dendritic cell subsets and their distinct functional roles and dependencies on thymocyte subsets for homeostasis and activation.

bioRxiv · Dec 18, 2023 · PreprintImmunology

CCR4 and CCR7 differentially regulate thymocyte subset localization with distinct outcomes for central tolerance

Y. Li, P. Guaman Tipan, H. J. Selden, J. Srinivasan, L. P. Hale, L. I. R. Ehrlich

This study shows CCR4 and CCR7 differentially regulate thymocyte subset localization and central tolerance outcomes through distinct mechanisms and APC interactions.

bioRxiv · Apr 3, 2022Immunology

An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment

J. Srinivasan, A. Vasudev, H. J. Selden, E. Perez, B. J. LaFleur, S. A. Sinari, A. Krueger, E. R. Richie, L. I. R. Ehrlich

The paper shows that early T-cell progenitors decline by 3 months in mice due to reduced pre-thymic progenitors and diminished Notch signaling.

bioRxiv · Jan 18, 2022 · PreprintImmunology

Central tolerance is impaired in the middle-aged thymic environment

J. N. Lancaster, D. L. Keatinge-Clay, J. Srinivasan, Y. Li, H. J. Selden, S. Nam, E. R. Richie, L. I. R. Ehrlich

This study shows that the middle-aged thymic environment impairs central tolerance by reducing mTECs and antigen-presenting cells, leading to less efficient negative selection and Treg induction.

bioRxiv · Jan 17, 2022Immunology