L. I. R. Ehrlich

The paper identifies seven thymic conventional dendritic cell subsets and their distinct functional roles and dependencies on thymocyte subsets for homeostasis and activation.

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

This study shows CCR4 and CCR7 differentially regulate thymocyte subset localization and central tolerance outcomes through distinct mechanisms and APC interactions.

The paper shows that early T-cell progenitors decline by 3 months in mice due to reduced pre-thymic progenitors and diminished Notch signaling.

This study shows that the middle-aged thymic environment impairs central tolerance by reducing mTECs and antigen-presenting cells, leading to less efficient negative selection and Treg induction.

This study identifies integrin-mediated adhesion and FAK/PYK2 signaling as critical for myeloid cell support of T-ALL, showing their role in survival and progression.