Author

E. R. Richie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

H. J. Selden· 2 shared J. Srinivasan· 2 shared L. I. R. Ehrlich· 2 shared A. Krueger· 1 shared A. Trofimov· 1 shared A. Vasudev· 1 shared B. J. LaFleur· 1 shared C. Cote· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

H. J. Selden

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3 papers

Recent·Most cited

Transposable elements regulate thymus development and function

J.-D. Larouche, C. M. Laumont, A. Trofimov, K. Vincent, L. Hesnard, S. Brochu, C. Cote, J. Humeau, E. Bonneil, J. Lanoix, C. Durette, P. Gendron, J.-P. Laverdure, E. R. Richie, S. Lemieux, , C. Perreault

This study investigates the role of transposable elements in thymus development and function, showing their interactions with transcription factors and their impact on T-cell tolerance.

bioRxiv · Jul 12, 2023Immunology

An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment

J. Srinivasan, A. Vasudev, H. J. Selden, E. Perez, B. J. LaFleur, S. A. Sinari, A. Krueger, E. R. Richie, L. I. R. Ehrlich

The paper shows that early T-cell progenitors decline by 3 months in mice due to reduced pre-thymic progenitors and diminished Notch signaling.

bioRxiv · Jan 18, 2022 · PreprintImmunology

Central tolerance is impaired in the middle-aged thymic environment

J. N. Lancaster, D. L. Keatinge-Clay, J. Srinivasan, Y. Li, H. J. Selden, S. Nam, E. R. Richie, L. I. R. Ehrlich

This study shows that the middle-aged thymic environment impairs central tolerance by reducing mTECs and antigen-presenting cells, leading to less efficient negative selection and Treg induction.

bioRxiv · Jan 17, 2022Immunology