Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies
H. Sawada, Y. Katsumata, H. Higashi, C. Zhang, Y. Li, S. Morgan, L. H. Lee, S. A. Singh, J. Z. Chen, D. A. Howatt, J. J. Moorleghen, M. K. Franklin, D. L. Rateri, Y. H. Shen, S. A. LeMaire, , A. Daugherty
This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.
bioRxiv · Feb 2, 2020Pathology