J. J. Moorleghen

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

This study examines how endogenous AngII levels change with exogenous AngII infusion and their impact on AAA and atherosclerosis in mice.

This study shows that inhibiting the AngII-AT1aR axis reduces aortic pathology in male Fbn1C1041G/+ mice, suggesting ligand-dependent AT1aR stimulation contributes to TAA progression.

This study introduces a para-spinal dorsal ultrasound approach to visualize descending aortic regions in mice, overcoming limitations of standard methods.

This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

This study shows hypercholesterolemia speeds up both the start and growth of angiotensin II-induced abdominal aortic aneurysms in mice.

This study shows that replacing amino acids 11 and 12 in mouse angiotensinogen with human counterparts does not affect renin cleavage or angiotensin II-mediated functions in mice.