Author

E. E. Vincent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:metabolism & bioenergetics· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 2 Assay:metabolomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

N. Jones· 5 shared M. Kollareddy· 3 shared A. C. Williams· 2 shared A. K. Holt· 2 shared D. N. Legge· 2 shared E. H. Ma· 2 shared J. Bellamy· 2 shared T. J. Collard· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersCancer Biology

N. Jones

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Glutamine addiction is targetable via altering splicing of nutrient sensors and epitranscriptome regulators

J. Bojko, M. Kollareddy, M. Szemes, J. Bellamy, E. Poon, A. Moukachar, D. Legge, E. E. Vincent, N. Jones, S. Malik, A. Greenhough, A. Paterson, J. H. Park, K. Gallacher, L. Chesler, K. Malik

This study shows PRMT5 inhibition targets MNA neuroblastoma by altering splicing of nutrient sensors and epitranscriptome regulators, leading to growth inhibition and apoptosis.

bioRxiv · Feb 28, 2024 · PreprintCancer Biology

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

A. K. Holt, A. K. Najumudeen, A. J. Hoskin, D. N. Legge, E. M. H. Mortensson, D. J. Flanagan, N. Jones, M. Kollareddy, T. J. Collard, P. Timms, O. J. Sansom, A. C. Williams, E. E. Vincent

This study shows aspirin reprograms colorectal cancer cell metabolism and increases sensitivity to glutaminase inhibition, suggesting potential for improved metabolic therapies in CRC.

bioRxiv · Aug 24, 2022Cancer Biology

Identifying targetable metabolic dependencies across colorectal cancer progression

D. N. Legge, E. Stanko, A. K. Holt, C. J. Bull, T. J. Collard, M. Kollareddy, J. Bellamy, S. Groves, E. H. Ma, E. Hazelwood, D. Qualtrough, B. Amulic, K. N. Malik, A. C. Williams, N. Jones, E. E. Vincent

This study identifies asparagine synthesis as a metabolic vulnerability in late-stage colorectal cancer cells, showing that blocking asparagine synthetase inhibits their proliferation.

bioRxiv · Mar 23, 2022Cancer Biology

A non-canonical role for glutamate decarboxylase 1 in cancer cell amino acid homeostasis, independent of the GABA shunt.

B. Samborska, T. Griss, E. H. Ma, N. Jones, K. S. Williams, A. Sergushichev, R. M. Johnson, E. Esaulova, E. Loginicheva, B. Flynn, J. Blagih, M. N. Artyomov, R. G. Jones, E. E. Vincent

This study identifies a non-canonical role for GAD1 in cancer cell amino acid homeostasis, independent of the GABA shunt, by regulating amino acid transporter expression.

bioRxiv · Feb 17, 2021 · PreprintCancer Biology

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors.

L. M. Scott, E. E. Vincent, N. Hudson, C. Neal, N. Jones, E. Lavelle, M. Campbell, A. Halestrap, A. D. Dick, S. Theodoropoulou

This study identifies IL-33 as a metabolic checkpoint in RPE cells that regulates mitochondrial respiration and metabolic adaptation to immune stressors.

bioRxiv · Feb 4, 2021Immunology