Author

D. Longley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

A. D. Corwin· 1 shared A. Garzia· 1 shared A. Hackett· 1 shared A. Santamaria-Pang· 1 shared A. Sood· 1 shared A. U. Lindner· 1 shared C. Adrain· 1 shared C. G. Gkogkas· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. D. Corwin

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

S. Chatterjee, P. Naeli, N. Simms, A. Garzia, A. Hackett, K. Coyle, P. Harris Snell, T. McGirr, T. N. Sawant, K. Dang, Z. V. Stoichkova, T. Alain, T. Tuschl, S. S. McDade, D. Longley, , S. M. Jafarnejad

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

bioRxiv · Dec 26, 2023Cell Biology

An atlas of inter- and intra-tumor heterogeneityof apoptosis competency in colorectal cancertissue at single cell resolution

A. U. Lindner, M. Salvucci, E. MCDonough, S. Cho, X. Stachtea, E. P. O'Connell, A. D. Corwin, A. Santamaria-Pang, S. Carberry, M. Fichtner, S. Van Schaeybroeck, P. Laurent-Puig, J. P. Burke, D. McNamara, M. Lawler, , J. H. Prehn

The paper generates an atlas of apoptosis susceptibility heterogeneity in colorectal cancer using single-cell analysis and ODE modeling, identifying intrinsic cellular differences in apoptosis competency.

bioRxiv · Mar 19, 2021Cancer Biology