Author

P. Naeli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. M. Jafarnejad· 3 shared A. Garzia· 2 shared N. Sonenberg· 2 shared P. Harris Snell· 2 shared S. Chatterjee· 2 shared T. Alain· 2 shared T. Duchaine· 2 shared X. Zhang· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

S. M. Jafarnejad

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3 papers

Recent·Most cited

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

S. Chatterjee, P. Naeli, N. Simms, A. Garzia, A. Hackett, K. Coyle, P. Harris Snell, T. McGirr, T. N. Sawant, K. Dang, Z. V. Stoichkova, T. Alain, T. Tuschl, S. S. McDade, D. Longley, , S. M. Jafarnejad

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

bioRxiv · Dec 26, 2023Cell Biology

SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression

P. Naeli, X. Zhang, P. Harris Snell, S. Chatterjee, M. Kamran, R. J. Ladak, N. Orr, T. Duchaine, N. Sonenberg, S. M. Jafarnejad

This study shows that SARS-CoV-2 NSP2 enhances miRNA-mediated translational repression by interacting with Argonaute 2 and the GIGYF2 complex.

bioRxiv · Jan 1, 2023Cell Biology

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

J.-H. Choi, X. Zhang, C. Zhang, D. L. Dai, J. Luo, R. Ladak, Q. Li, S. Wiebe, A. C. H. Liu, X. Ran, J. Yang, P. Naeli, A. Garzia, L. Zhou, N. Mahmood, , N. Sonenberg

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology