Author

S. Van Schaeybroeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. H. M. Prehn· 3 shared M. Salvucci· 3 shared A. Santamaria-Pang· 2 shared A. Sood· 2 shared A. U. Lindner· 2 shared D. B. Longley· 2 shared E. MCDonough· 2 shared F. Ginty· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

J. H. M. Prehn

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5 papers

Recent·Most cited

Bcl-xL is a key mediator of apoptosis following KRASG12C inhibition in KRASG12C mutant colorectal cancer.

H. Khawaja, R. Briggs, C. Latimer, M. Rassel, D. Griffin, L. Hanson, A. Bardelli, F. Di Nicolantonio, S. S. McDade, C. J. Scott, S. Lambe, M. Maurya, A. U. Lindner, J. H. M. Prehn, J. Sousa, , S. Van Schaeybroeck

This study identifies Bcl-xL as a mediator of resistance to KRASG12C inhibitors in colorectal cancer and shows that combining Bcl-xL inhibition with KRASG12C inhibition enhances apoptosis and reduces tumor growth.

bioRxiv · May 10, 2022Cancer Biology

An atlas of inter- and intra-tumor heterogeneityof apoptosis competency in colorectal cancertissue at single cell resolution

A. U. Lindner, M. Salvucci, E. MCDonough, S. Cho, X. Stachtea, E. P. O'Connell, A. D. Corwin, A. Santamaria-Pang, S. Carberry, M. Fichtner, S. Van Schaeybroeck, P. Laurent-Puig, J. P. Burke, D. McNamara, M. Lawler, , J. H. Prehn

The paper generates an atlas of apoptosis susceptibility heterogeneity in colorectal cancer using single-cell analysis and ODE modeling, identifying intrinsic cellular differences in apoptosis competency.

bioRxiv · Mar 19, 2021Cancer Biology

Stratification Of Chemotherapy-Treated Stage III Colorectal Cancer Patients Using Multiplexed Imaging And Single Cell Analysis Of T Cell Populations

X. Stachtea, M. B. Loughrey, M. Salvucci, A. Lindner, S. Cho, E. McDonough, A. Sood, J. Graf, A. Santamaria-Pang, A. Corwin, P. Laurent-Puig, S. Dasgupta, S. Van Schaeybroeck, M. Lawler, J. H. M. Prehn, , D. B. Longley

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

bioRxiv · Feb 24, 2021Cancer Biology

Modulating the unfolded protein response: Impacts of radiation on the response of prostate cancer cells to ONC201

F. Amoroso, K. Glass, F. Liberal, R. Steele, S. Maguire, R. Tarapore, J. Allen, S. Van Schaeybroeck, K. Butterworth, K. Prise, J. O'Sullivan, S. Jain, D. Waugh, I. Mills

This study investigates how radiation and ONC201 modulate the unfolded protein response (UPR) in prostate cancer cells, enhancing cell death and radiosensitivity.

Scientific Reports · Feb 19, 2021Peer-reviewedCancer Biology

TRAIL signalling promotes entosis in colorectal cancer

E. Bozkurt, H. Dussmann, M. Salvucci, B. Cavanagh, S. Van Schaeybroeck, D. B. Longley, S. J. Martin, J. H. M. Prehn

This study identifies TRAIL as a promoter of entosis in colorectal cancer cells and links CICs to poor patient prognosis.

bioRxiv · Sep 29, 2020Cancer Biology