Author

J. H. Prehn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. Salvucci· 2 shared A. D. Corwin· 1 shared A. S. M. Magee· 1 shared A. Santamaria-Pang· 1 shared A. Sood· 1 shared A. U. Lindner· 1 shared B. J. P. Huntly· 1 shared C. Mappereley· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

M. Salvucci

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Author profile →

3 papers

Recent·Most cited

Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.

K. Woodley, L. S. Dillingh, G. Giotopoulos, P. Madrigal, K. M. Rattigan, C. Philippe, V. Dembitz, A. S. M. Magee, R. Asby, L. N. van de Lagemaat, C. Mappereley, S. C. James, J. H. Prehn, K. Tzelepis, K. Rouault-Pierre, , P. Gallipoli

This study shows that inhibiting mannose metabolism sensitizes AML cells to cytarabine and FLT3 inhibitors by promoting ferroptotic cell death through fatty acid metabolism changes.

bioRxiv · May 16, 2022Cancer Biology

Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC)

M. Salvucci, N. T. Crawford, K. Stott, S. Bullman, D. B. Longley, J. H. Prehn

bioRxiv · May 17, 2021Cancer Biology

An atlas of inter- and intra-tumor heterogeneityof apoptosis competency in colorectal cancertissue at single cell resolution

A. U. Lindner, M. Salvucci, E. MCDonough, S. Cho, X. Stachtea, E. P. O'Connell, A. D. Corwin, A. Santamaria-Pang, S. Carberry, M. Fichtner, S. Van Schaeybroeck, P. Laurent-Puig, J. P. Burke, D. McNamara, M. Lawler, , J. H. Prehn

The paper generates an atlas of apoptosis susceptibility heterogeneity in colorectal cancer using single-cell analysis and ODE modeling, identifying intrinsic cellular differences in apoptosis competency.

bioRxiv · Mar 19, 2021Cancer Biology