Inflammation causes insulin resistance via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels
S. Yan, A. Santoro, M. J. Niphakis, A. M. Pinto, C. L. Jacobs, R. Ahmad, R. M. Suciu, B. R. Fonslow, R. B. Herbst-Graham, N. Ngo, C. L. Henry, D. M. Herbst, A. Saghatelian, B. B. Kahn, E. D. Rosen
This study identifies the IRF3/AIG1 axis in adipocytes as a mechanism linking obesity-induced inflammation to insulin resistance and suggests AIG1 inhibition as a therapeutic approach.
bioRxiv · Aug 8, 2023 · PreprintPhysiology