Author

E. D. Rosen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Tenen· 2 shared A. Courcoulas· 1 shared A. De Vincenzo· 1 shared A. Giordano· 1 shared A. Gulko· 1 shared A. Kar· 1 shared A. L. Essene· 1 shared A. Lyubetskaya· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

D. Tenen

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Author profile →

3 papers

Recent·Most cited

Inflammation causes insulin resistance via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

S. Yan, A. Santoro, M. J. Niphakis, A. M. Pinto, C. L. Jacobs, R. Ahmad, R. M. Suciu, B. R. Fonslow, R. B. Herbst-Graham, N. Ngo, C. L. Henry, D. M. Herbst, A. Saghatelian, B. B. Kahn, E. D. Rosen

This study identifies the IRF3/AIG1 axis in adipocytes as a mechanism linking obesity-induced inflammation to insulin resistance and suggests AIG1 inhibition as a therapeutic approach.

bioRxiv · Aug 8, 2023 · PreprintPhysiology

A single cell atlas of human and mouse white adipose tissue

M. P. Emont, C. Jacobs, A. L. Essene, D. Pant, D. Tenen, G. Colleluori, A. De Vincenzo, A. M. Jorgensen, H. Dashti, A. Stefek, E. McGonagle, S. Strobel, S. Laber, S. Agrawal, G. P. Westcott, , E. D. Rosen

This study creates single-cell atlases of human and mouse white adipose tissue, identifying cell types and their roles in metabolic disease across different body weights and diets.

bioRxiv · Nov 9, 2021Physiology

Thermoneutrality induces skeletal muscle myopathy via brown adipose tissue in an IRF4- and myostatin-dependent manner

X. Kong, P. Zhou, T. Yao, L. Kazak, D. Tenen, A. Lyubetskaya, B. Dawes, L. Tsai, B. Kahn, B. Spiegelman, T. Liu, E. D. Rosen

This study shows that thermoneutrality causes skeletal muscle myopathy through brown adipose tissue via IRF4 and myostatin mechanisms.

bioRxiv · Mar 2, 2018Physiology