Author

D. M. Peacock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. M. Shokat· 2 shared B. F. Binkowski· 1 shared C. A. Zimprich· 1 shared C. R. Corona· 1 shared J. A. Walker· 1 shared J. D. Vasta· 1 shared M. B. Robers· 1 shared M. J. S. Kelly· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

K. M. Shokat

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2 papers

Recent·Most cited

Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy

D. M. Peacock, M. J. S. Kelly, K. M. Shokat

This paper uses 19F NMR spectroscopy with trifluoromethyl ligands to assess nucleotide state occupancy in KRas proteins, identifying selective structures for KRasG12D.

bioRxiv · Jul 15, 2022Cancer Biology

KRAS is vulnerable to reversible switch-II pocket engagement in cells

J. D. Vasta, D. M. Peacock, Q. Zheng, J. A. Walker, Z. Zhang, C. A. Zimprich, M. R. Thomas, M. T. Beck, B. F. Binkowski, C. R. Corona, M. B. Robers, K. M. Shokat

The paper investigates the accessibility of the switch-II pocket in various KRAS mutants using NMR and a cellular engagement assay, showing it is accessible with non-covalent ligands regardless of GDP state.

Nature Chemical Biology · Mar 21, 2022Peer-reviewedCancer Biology