Author

C. A. Zimprich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

C. R. Corona· 2 shared J. D. Vasta· 2 shared M. B. Robers· 2 shared A. Lewis· 1 shared B. F. Binkowski· 1 shared C. A. Bingman· 1 shared C. R. M. Asquith· 1 shared D. J. Pagliarini· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

C. R. Corona

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Small Molecule Modulation of the Archetypal UbiB protein COQ8

N. H. Murray, A. Lewis, C. R. M. Asquith, J. P. R. Pabon, Z. Fang, N. Ptak, R. W. Smith, J. D. Vasta, C. A. Zimprich, C. R. Corona, M. B. Robers, C. A. Bingman, M. L. Gross, K. Henzler-Wildman, D. J. Pagliarini

The paper develops small molecule inhibitors and activators for COQ8A, a UbiB family protein, using crystallography, NMR, and mass spectrometry to modulate its function in CoQ biosynthesis.

bioRxiv · Mar 22, 2022 · PreprintBiochemistry

KRAS is vulnerable to reversible switch-II pocket engagement in cells

J. D. Vasta, D. M. Peacock, Q. Zheng, J. A. Walker, Z. Zhang, C. A. Zimprich, M. R. Thomas, M. T. Beck, B. F. Binkowski, C. R. Corona, M. B. Robers, K. M. Shokat

The paper investigates the accessibility of the switch-II pocket in various KRAS mutants using NMR and a cellular engagement assay, showing it is accessible with non-covalent ligands regardless of GDP state.

Nature Chemical Biology · Mar 21, 2022Peer-reviewedCancer Biology