eEF2 kinase enhances the expression of PD-L1 by promoting the translation of its mRNA
C. G. Proud, Y. Wu, J. Xie, X. Jin, R. V. Lenchine, X. Wang, D. M. W. Fang, Z. NASSAR, L. M. Butler, J. Li
This study shows that eEF2K enhances PD-L1 expression by promoting its mRNA translation through a uORF in the 5-UTR, making cancer cells more vulnerable to immune attack.
bioRxiv · Sep 1, 2020Biochemistry