S. Ortega

The mechanoreceptor PIEZO1 is a novel oncogene in glioma by promoting astrocyte reactivity

This study identifies PIEZO1 as an oncogene in glioma that promotes astrocyte reactivity and is associated with worse prognosis in male patients.

PP2A-B55alpha,delta phosphatase counteracts Ki67-dependent chromosome individualization during mitosis

The paper identifies PP2A-B55alpha,delta phosphatase as counteracting Ki67-dependent chromosome individualization during mitosis in mice.

Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135

This study shows that Cep135 loss causes microcephaly in mice through p53-independent mechanisms due to neural progenitor adaptation failure to centriole defects.

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

This study shows that overexpressing Cpt1a in renal tubular epithelial cells reduces fibrosis by restoring mitochondrial function and bioenergetics in CKD models and human patients.

Antimetastatic dsRNA mimics identified by live imaging of pathogenic neolymphangiogenesis

The paper identifies dsRNA mimics as inhibitors of lymphangiogenesis and metastasis using live imaging models of melanoma.

A novel microRNA-based strategy to expand the differentiation potency of stem cells

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.

Do El Nino events beget generations of reproductively deficient adults?

The paper tests whether El Nino events reduce reproductive success in subsequent generations of blue-footed boobies but finds no such deficits.