J. M. Flynn

Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation

Contributions of hyperactive mutations in Mpro from SARS-CoV-2 to drug resistance

This study identifies hyperactive mutations in SARS-CoV-2 Mpro that increase enzyme activity and contribute to drug resistance, finding them more prevalent than binding-reducing mutations.

A complete allosteric map of a GTPase switch in its native network

The paper systematically identifies new allosteric regulatory sites in Gsp1/Ran by mutational scanning, revealing that many deleterious mutations affect function outside the active site through allosteric coupling.

Genome assembly, structural variants, and genetic differentiation between Lake Whitefish young species pairs (Coregonus sp.) with long and short reads

The paper assembles genomes and identifies structural variants in two Lake Whitefish species pairs using long and short reads, finding that SVs cover more genome than SNPs and are linked to transposable elements.

Three recent sex chromosome-to-autosome fusions in a Drosophila virilis strain with high satellite content

This paper describes three recent sex chromosome-to-autosome fusions in a Drosophila virilis strain, linking satellite DNA abundance to increased genome instability and karyotype variability.

Copy number evolution in simple and complex tandem repeats across the C57BL/6 and C57BL/10 inbred mouse lines

The paper estimates copy number change rates in tandem repeats across mouse lines over generations, finding stability in CAG repeats and variation in other repeats.

Comprehensive fitness maps of Hsp90 show widespread environmental dependence

This study maps the fitness effects of Hsp90 variants across multiple environments, showing widespread environmental dependence and selection for robustness.

Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

The paper measures the fitness effects of historical amino acid substitutions in Hsp90 across evolutionary timescales, finding pervasive epistasis influencing sequence evolution and entrenchment.

Selection constrains high rates of satellite DNA mutation in Daphnia pulex

This study quantifies mutation rates and selective pressures on satellite DNA in Daphnia pulex, showing high mutation rates and evidence of purifying selection in non-MA population isolates.

Resource-Driven Encounters and the Induction of Disease Among Consumers

The paper models how resource availability affects encounter rates among jackals and investigates how disease outbreaks in zebras can indirectly induce disease in jackals.

Genome-wide survey of Pseudomonas aeruginosa PA14 reveals a role for the glyoxylate pathway and extracellular proteases in the limited utilization of mucin

This study identifies genes in Pseudomonas aeruginosa essential for mucin utilization, highlighting the glyoxylate pathway and proteases like LasB and AprA.