Author

D. P. Claxton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:electronic health records· 1

Frequent Co-Authors

H. S. Mchaourab· 3 shared R. A. Stein· 2 shared A. K. Kenworthy· 1 shared B. Han· 1 shared D. Williams· 1 shared E. Binshtein· 1 shared E. Gouaux· 1 shared E. Karakas· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

H. S. Mchaourab

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular mechanisms of functional impairment for active site mutations in glucose-6-phosphatase catalytic subunit 1 linked to glycogen storage disease.

M. Sinclair, R. A. Stein, J. Sheehan, E. M. Hawes, R. M. O'Brien, E. Tajkhorshid, D. P. Claxton

This study identifies atomic interactions and energetic perturbations in G6PC1 active site mutations linked to glycogen storage disease type 1a using computational models and experimental validation.

bioRxiv · Mar 13, 2023Biophysics

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

B. Han, J. C. Porta, J. L. Hanks, Y. Peskova, E. Binshtein, K. Dryden, D. P. Claxton, H. S. Mchaourab, E. Karakas, M. D. Ohi, A. K. Kenworthy

This study uses single particle electron microscopy to reveal the structure of human CAV1 8S complexes, showing they are toroidal with distinct rings and stalks, and provides insights into their assembly.

bioRxiv · Jun 4, 2020Cell Biology

Sequence and Structural Determinants of Ligand-dependent Alternating Access of a MATE Transporter

K. L. Jagessar, D. P. Claxton, R. A. Stein, H. S. Mchaourab

This study identifies sequence and structural determinants of ligand-dependent alternating access in PfMATE using DEER, mutagenesis, and functional assays.

bioRxiv · Sep 18, 2019Biophysics

Expression and purification of a functional heteromeric GABAA receptor for structural studies

D. P. Claxton, E. Gouaux

This paper describes methods to express and purify functional GABAA receptors for structural studies, identifying a minimal construct that retains agonist binding activity.

bioRxiv · May 9, 2018Biochemistry

Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity

S. Mishra, S. A. Chandler, D. Williams, D. P. Claxton, H. A. Koteiche, P. L. Stewart, J. L. P. Benesch, H. S. Mchaourab

This study engineers a polydisperse small heat-shock protein to reveal conserved motifs of oligomer plasticity through structural and functional analysis.

bioRxiv · Jan 12, 2018Biochemistry