Author

A. K. Kenworthy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Research Focus:protein structure prediction· 3 Approach:deep learning· 2 Approach:microscopy & imaging analysis· 2 Assay:protein structure· 2

Frequent Co-Authors

B. Han· 5 shared A. Gulsevin· 4 shared E. Karakas· 4 shared J. Meiler· 4 shared M. D. Ohi· 4 shared H. Mchaourab· 3 shared J. C. Porta· 3 shared S. Connolly· 3 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersBiophysics

B. Han

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Author profile →

9 papers

Recent·Most cited

Lipid peroxidation drives liquid-liquid phase separation and disrupts raft protein partitioning in biological membranes

M. Balakrishnan, A. K. Kenworthy

This study shows lipid peroxidation enhances phase separation in membranes, disrupts raft protein partitioning, and alters membrane structure and stability.

bioRxiv · Sep 12, 2023Biophysics

Evolutionarily diverse caveolins share a common structural framework built around amphipathic discs

B. Han, S. Connolly, L. F. L. Wilson, D. T. Schultz, A. Gulsevin, J. Meiler, E. Karakas, M. D. Ohi, A. K. Kenworthy

The paper predicts structures for 73 caveolins across animal diversity and identifies conserved structural elements and amphipathic disc assembly, revealing an ancient structural framework predating Metazoa.

bioRxiv · Nov 15, 2022Biophysics

Template-free prediction of a new monotopic membrane protein fold and oligomeric assembly by Alphafold2

A. Gulsevin, B. Han, J. C. Porta, H. Mchaourab, J. Meiler, A. K. Kenworthy

This study uses AlphaFold2 to predict the structure of caveolin-1, revealing its new fold and oligomeric assembly, but notes limitations in predicting higher-order complexes.

bioRxiv · Jul 12, 2022Biophysics

Structural characterization of a breast cancer-associated mutation in caveolin-1

B. Han, A. Gulsevin, S. Connolly, T. Wang, J. Porta, A. Tiwari, A. Deng, L. Chang, Y. Peskova, H. Mchaourab, E. Karakas, M. D. Ohi, J. Meiler, A. K. Kenworthy

This study examines how a breast cancer-associated mutation in CAV1, P132L, affects its structure and oligomerization, revealing its impact on caveolae formation.

bioRxiv · May 23, 2022 · PreprintBiophysics

Molecular architecture of the human caveolin-1 complex

J. C. Porta, B. Han, A. Gulsevin, J. Chung, Y. Peskova, S. Connolly, H. Mchaourab, J. Meiler, E. Karakas, A. K. Kenworthy, M. D. Ohi

The paper uses cryo-electron microscopy to reveal the structure of the human caveolin-1 complex, showing it forms a disc with a flat membrane-binding surface.

bioRxiv · Feb 17, 2022Biophysics

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

B. Han, J. C. Porta, J. L. Hanks, Y. Peskova, E. Binshtein, K. Dryden, D. P. Claxton, H. S. Mchaourab, E. Karakas, M. D. Ohi, A. K. Kenworthy

This study uses single particle electron microscopy to reveal the structure of human CAV1 8S complexes, showing they are toroidal with distinct rings and stalks, and provides insights into their assembly.

bioRxiv · Jun 4, 2020Cell Biology

Peripheral Myelin Protein 22 Preferentially Partitions into Ordered Phase Membrane Domains

J. T. Marinko, G. C. Li, A. K. Kenworthy, C. R. Sanders

This paper shows that PMP22 preferentially partitions into ordered membrane domains, and disease mutations disrupt this preference.

bioRxiv · Jan 28, 2020Biophysics

Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin

A. M. Kabbani, K. Raghunathan, W. I. Lencer, A. K. Kenworthy, C. V. Kelly

This study shows that cholera toxin subunit B induces membrane curvature only when bound to multiple GM1 receptors, highlighting the importance of structured clustering for this process.

bioRxiv · Jan 22, 2020Biophysics

Graphene nanoflakes for acute manipulation of membrane cholesterol and transmembrane signaling

K. E. Kitko, T. Hong, R. M. Lazarenko, R. J. Montenegro-Burke, A. T. Shah, Y. Zhang, K. Raghunathan, A. K. Kenworthy, M. C. Skala, J. A. McLean, Y.-Q. Xu, Q. Zhang

This study shows graphene nanoflakes manipulate membrane cholesterol, altering cell signaling in fibroblasts and neurons.

bioRxiv · Mar 18, 2019 · PreprintCell Biology