Author

E. Binshtein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 11 Approach:experimental assay· 9 Assay:proteomics· 8 Research Focus:host-pathogen & immune response· 7 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3

Frequent Co-Authors

J. E. Crowe· 11 shared P. Gilchuk· 7 shared R. H. Carnahan· 7 shared A. Trivette· 6 shared E. C. Chen· 6 shared N. Suryadevara· 6 shared L. Myers· 5 shared M. S. Diamond· 5 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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11 shared papersImmunology

J. E. Crowe

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

T. A. Desautels, K. T. Arrildt, A. T. Zemla, E. Y. Lau, F. Zhu, D. Ricci, S. Cronin, S. Zost, E. Binshtein, S. M. Scheaffer, B. Dadonaite, B. K. Petersen, T. B. Engdahl, E. Chen, L. S. Handal, , Carnahan

This paper computationally redesigns an antibody to restore potency against SARS-CoV-2 Omicron subvariants while maintaining efficacy against Delta and other variants.

bioRxiv · Oct 21, 2022Microbiology

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

T. B. Engdahl, E. Binshtein, R. L. Brocato, N. A. A. Kuzmina, L. M. Principe, S. A. Kwilas, R. K. Kim, N. S. Chapman, M. S. Porter, P. Guardado-Calvo, F. A. Rey, L. S. Handal, S. M. Diaz, I. A. Zagol-Ikapitte, J. X. Reidy, , J. E. Crowe

This study maps antigenic sites and characterizes neutralizing antibodies against hantaviruses, identifying mechanisms and cross-protective potential for vaccine development.

bioRxiv · Jul 19, 2022Immunology

Systematic analysis of human antibody response to ebolavirus glycoprotein reveals high prevalence of neutralizing public clonotypes

E. C. Chen, P. Gilchuk, S. J. Zost, P. A. Ilinykh, E. Binshtein, K. Huang, L. Myers, S. Bonissone, S. Day, C. R. Kona, A. Trivette, J. X. Reidy, R. E. Sutton, C. Gainza, S. Monroig, , J. E. Crowe

The paper analyzes the human antibody response to ebolavirus glycoprotein, identifying public clonotypes with neutralizing activity and implications for vaccine design.

bioRxiv · Jan 12, 2022 · PreprintImmunology

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

N. Suryadevara, A. Shiakolas, L. VanBlargan, E. Binshtein, R. Chen, J. B. Case, K. Kramer, E. Armstrong, L. Myers, A. Trivette, C. Gainza, R. Nargi, C. Selverian, E. Davidson, B. Doranz, , J. E. Crowe

The paper identifies a rare antibody that targets the SARS-CoV-2 spike trimer interface, disrupting viral entry and providing protection in mice.

bioRxiv · Jan 12, 2022Immunology

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

E. C. Chen, P. Gilchuk, S. J. Zost, N. Suryadevara, E. S. Winkler, C. R. Cabel, E. Binshtein, R. E. Sutton, J. L. Rodriguez, S. Day, L. Myers, A. Trivette, J. K. Williams, E. Davidson, S. Li, , J. E. Crowe

The paper identifies public antibody clonotypes in SARS-CoV-2 convalescents and vaccinated individuals, revealing common epitope recognition and potential vaccine efficacy mechanisms.

bioRxiv · May 2, 2021Immunology

Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

M. P. Doyle, N. Kose, V. Borisevich, E. Binshtein, M. Amaya, M. Nagel, E. J. Annand, E. Armstrong, R. Bombardi, J. Dong, K. L. Schey, C. C. Broder, L. Zeitlin, E. Kuang, Z. Bornholdt, , J. E. Crowe

This study identifies human monoclonal antibodies that neutralize HeV and NiV by targeting distinct antigenic sites on the receptor binding protein and demonstrates their cooperative binding and synergistic therapeutic effects.

bioRxiv · Feb 17, 2021Immunology

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

J. Dong, S. Zost, A. Greaney, T. N. Starr, A. S. Dingens, E. C. Chen, R. Chen, B. Case, R. Sutton, P. Gilchuk, J. Rodriguez, E. Armstrong, C. Gainza, R. Nargi, E. Binshtein, , J. E. Crowe

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

bioRxiv · Jan 27, 2021 · PreprintImmunology

Neutralizing and protective human monoclonal antibodies recognizing the N-terminaldomain of the SARS-CoV-2 spike protein

N. Suryadevara, S. Shrihari, P. Gilchuk, L. VanBlargan, E. Binshtein, S. Zost, R. Nargi, R. Sutton, E. S. Winkler, E. C. Chen, M. E. Fouch, E. Davidson, B. Doranz, R. H. Carnahan, L. Thackray, , J. E. Crowe

The paper identifies two NTD-specific human mAbs with neutralizing activity against SARS-CoV-2 and shows they require Fc effector functions for optimal protection.

bioRxiv · Jan 19, 2021Immunology

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

A. J. Greaney, T. N. Starr, P. Gilchuk, S. J. Zost, E. Binshtein, A. N. Loes, S. K. Hilton, J. Huddleston, R. Eguia, K. H. Crawford, A. S. Dingens, R. S. Nargi, R. E. Sutton, N. Suryadevara, P. W. Rothlauf, , J. D. Bloom

This study maps mutations in the SARS-CoV-2 spike RBD that escape antibody recognition, revealing escape mutation patterns and enabling the design of antibody cocktails.

bioRxiv · Sep 10, 2020Microbiology

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

B. Han, J. C. Porta, J. L. Hanks, Y. Peskova, E. Binshtein, K. Dryden, D. P. Claxton, H. S. Mchaourab, E. Karakas, M. D. Ohi, A. K. Kenworthy

This study uses single particle electron microscopy to reveal the structure of human CAV1 8S complexes, showing they are toroidal with distinct rings and stalks, and provides insights into their assembly.

bioRxiv · Jun 4, 2020Cell Biology

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

S. J. Zost, P. Gilchuk, J. B. Case, E. Binshtein, R. E. Chen, J. X. Reidy, A. Trivette, R. S. Nargi, R. E. Sutton, N. Suryadevara, L. E. Williamson, E. C. Chen, T. Jones, S. Day, L. Myers, , J. E. Crowe

The paper identifies potent neutralizing antibodies against SARS-CoV-2 that block receptor binding and protect animals, providing insights for vaccine and therapy development.

bioRxiv · May 22, 2020Immunology

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

S. J. Zost, P. Gilchuk, R. Chen, J. B. Case, J. X. Reidy, A. Trivette, R. S. Nargi, R. E. Sutton, N. Suryadevara, E. C. Chen, E. Binshtein, S. Shrihari, M. A. Ostrowski, H. Y. Chu, J. E. Didier, , J. E. Crowe

This study isolates and profiles human monoclonal antibodies against SARS-CoV-2 spike protein, identifying neutralizing antibodies targeting the receptor-binding domain.

bioRxiv · May 12, 2020Immunology

Mammalian retromer is an adaptable scaffold for cargo sorting from endosomes

A. K. Kendall, B. Xie, P. Xu, J. Wang, R. Burcham, M. N. Frazier, E. Binshtein, H. Wei, T. R. Graham, T. Nakagawa, L. P. Jackson

This study identifies adaptable retromer structures and their role in cargo sorting from endosomes to the TGN or plasma membrane in mammals.

bioRxiv · May 15, 2019Cell Biology