Author

D. P. Nussbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. M. Eckhoff· 2 shared M. K. Iyer· 2 shared P. J. Allen· 2 shared A. A. Fletcher· 1 shared A. Barrera· 1 shared A. Dohlman· 1 shared A. E. Stewart· 1 shared A. Fletcher· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

A. M. Eckhoff

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comprehensive Assessment of the Intrinsic Pancreatic Microbiome

A. M. Eckhoff, A. A. Fletcher, M. S. Kelly, A. Dohlman, C. A. McIntyre, X. Shen, M. K. Iyer, D. P. Nussbaum, P. J. Allen

This study profiles the pancreatic microbiome in patients with benign, precancerous, and cancerous conditions, finding a low-biomass, low-diversity microbiome that does not differ across disease states.

bioRxiv · Aug 12, 2023Microbiology

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

D. P. Nussbaum, C. A. Martz, A. M. Waters, A. Barrera, J. C. Rutter, C. G. Cerda-Smith, A. E. Stewart, C. Wu, M. Cakir, C. B. Levandowski, D. E. Kantrowitz, S. J. McCall, M. Pierobon, E. Petricoin, J. J. Smith, , K. C. Wood

This study shows that Mediator kinase inhibition prevents resistance to ERK/MAPK inhibitors in KRAS-mutant cancers by blocking transcriptional plasticity.

bioRxiv · Sep 17, 2022 · PreprintCancer Biology

Digital Spatial Profiling of Intraductal Papillary Mucinous Neoplasms: Towards a Molecular Framework for Risk Stratification

P. J. Allen, M. K. Iyer, C. Shi, A. M. Eckhoff, A. Fletcher, D. P. Nussbaum

The paper uses spatial RNA profiling to identify molecular markers and insights into malignant progression in intraductal papillary mucinous neoplasms (IPMN).

bioRxiv · Sep 8, 2022Cancer Biology