Author

A. E. Stewart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Barrera· 1 shared A. M. Gilbert· 1 shared A. M. Waters· 1 shared A. Nagata· 1 shared A. R. Nager· 1 shared B. Bolanos· 1 shared B. F. Cravatt· 1 shared B. Melillo· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Barrera

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Expanding the ligandable proteome by paralog hopping with covalent probes

Y. Zhang, Z. Liu, M. Hirschi, O. Brodsky, E. Johnson, S. J. Won, A. Nagata, M. D. Petroski, J. D. Majmudar, S. Niessen, T. VanArsdale, A. M. Gilbert, M. M. Hayward, A. E. Stewart, A. R. Nager, , B. F. Cravatt

The paper uses covalent probes and paralog hopping to identify ligandable pockets in proteins lacking cysteines, demonstrating a method to expand the ligandable proteome.

bioRxiv · Jan 18, 2024 · PreprintBiochemistry

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

D. P. Nussbaum, C. A. Martz, A. M. Waters, A. Barrera, J. C. Rutter, C. G. Cerda-Smith, A. E. Stewart, C. Wu, M. Cakir, C. B. Levandowski, D. E. Kantrowitz, S. J. McCall, M. Pierobon, E. Petricoin, J. J. Smith, , K. C. Wood

This study shows that Mediator kinase inhibition prevents resistance to ERK/MAPK inhibitors in KRAS-mutant cancers by blocking transcriptional plasticity.

bioRxiv · Sep 17, 2022 · PreprintCancer Biology

Structural basis for Nirmatrelvir in vitro efficacy against SARS-CoV-2 variants

S. E. Greasley, S. Noell, O. Plotnikova, R. A. Ferre, W. Liu, B. Bolanos, K. F. Fennell, J. Nicki, T. Craig, Y. Zhu, A. E. Stewart, C. M. Steppan

This study evaluates nirmatrelvir's in vitro efficacy against SARS-CoV-2 variants, finding it maintains potency against Omicron and other variants.

bioRxiv · Jan 17, 2022Biochemistry