Author

J. C. Rutter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

A. Barrera· 1 shared A. E. Stewart· 1 shared A. M. Schmoker· 1 shared A. M. Waters· 1 shared B. J. Groendyke· 1 shared B. L. Ebert· 1 shared B. Sandoval· 1 shared C. A. Martz· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Barrera

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Author profile →

2 papers

Recent·Most cited

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

M. M. Hassan, Y.-D. Li, M. W. Ma, M. Teng, W. S. Byun, K. Puvar, R. Lumpkin, B. Sandoval, J. C. Rutter, C. Y. Jin, M. Y. Wang, S. Xu, A. M. Schmoker, H. Cheong, B. J. Groendyke, , N. Gray

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

bioRxiv · Oct 7, 2023 · PreprintPharmacology & Toxicology

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

D. P. Nussbaum, C. A. Martz, A. M. Waters, A. Barrera, J. C. Rutter, C. G. Cerda-Smith, A. E. Stewart, C. Wu, M. Cakir, C. B. Levandowski, D. E. Kantrowitz, S. J. McCall, M. Pierobon, E. Petricoin, J. J. Smith, , K. C. Wood

This study shows that Mediator kinase inhibition prevents resistance to ERK/MAPK inhibitors in KRAS-mutant cancers by blocking transcriptional plasticity.

bioRxiv · Sep 17, 2022 · PreprintCancer Biology