The ASCC2 CUE domain contacts adjacent ubiquitins to recognize K63-linked polyubiquitin
P. M. Lombardi, S. Haile, T. Rusanov, R. Rodell, R. Anoh, J. G. Baer, K. A. Burke, L. N. Gray, A. R. Hacker, K. R. Kebreau, C. K. Ngandu, H. A. Orland, E. Osei-Asante, D. P. Schmelyun, D. E. Shorb, , C. Wolberger
This study shows that the ASCC2 CUE domain binds K63-linked diubiquitin by interacting with both ubiquitins, with unique contacts to the proximal ubiquitin that are critical for ASCC2 recruitment during DNA alkylation response.
bioRxiv · Oct 17, 2021 · PreprintBiophysics