BiophysicsbioRxivPreprint
The ASCC2 CUE domain contacts adjacent ubiquitins to recognize K63-linked polyubiquitin
P. M. Lombardi, S. Haile, T. Rusanov…·C. Wolberger
This study shows that the ASCC2 CUE domain binds K63-linked diubiquitin by interacting with both ubiquitins, with unique contacts to the proximal ubiquitin that are critical for ASCC2 recruitment during DNA alkylation response.
DOI 10.1101/2021.10.17.464694