Author

R. C. MacLean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:metagenomics· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

R. M. Wheatley· 3 shared A. Oliver· 2 shared L. P. Shaw· 2 shared S. Lindon· 2 shared S. Shah· 2 shared A. Quinn· 1 shared A. Ruzin· 1 shared B. Britto Xavier· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

R. M. Wheatley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Adaptation of Pseudomonas aeruginosa to repeated invasion into a commensal competitor

R. M. Wheatley, L. P. Shaw, S. Shah, S. Lindon, R. C. MacLean

This study examines how Pseudomonas aeruginosa adapts to repeated invasion of Staphylococcus epidermidis, showing divergent evolutionary responses between monoculture and coculture conditions.

bioRxiv · Mar 19, 2024 · PreprintMicrobiology

Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade the respiratory microbiome

S. Lindon, S. Shah, D. R. Gifford, M. A. Gomis Font, D. Kaur, A. Oliver, R. C. MacLean, R. M. Wheatley

This study shows antibiotic resistance in Pseudomonas aeruginosa can both help and hinder its ability to invade respiratory microbiomes, depending on the commensal microbes involved.

bioRxiv · Nov 14, 2023 · PreprintMicrobiology

Restriction-modification systems have shaped the evolution and distribution of plasmids across bacteria

L. P. Shaw, E. P. C. Rocha, R. C. MacLean

This study shows plasmids avoid restriction-modification system targets, with smaller plasmids adapting via sequence composition and larger ones via protective genes.

bioRxiv · Dec 15, 2022Microbiology

Polyclonal pathogen populations accelerate the evolution of antibiotic resistance in patients

J. Diaz Caballero, R. M. Wheatley, N. Kapel, C. Lopez-Causape, T. Van der Schalk, A. Quinn, C. Recanatini, B. Britto Xavier, L. Timbermont, J. Kluytmans, A. Ruzin, M. Esser, S. Malhotra-Kumar, A. Oliver, R. C. MacLean, WP3A working group

Antibiotic resistance evolves quickly in patients colonized by polyclonal pathogen populations.

bioRxiv · Dec 10, 2021 · PreprintEvolutionary Biology