Author

D. Roxbury

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

M. A. Gravely· 3 shared M. M. Safaee· 3 shared D. A. Heller· 2 shared P. V. Jena· 2 shared A. Jamieson· 1 shared A. Kindopp· 1 shared A. Nadeem· 1 shared A. S. Haka· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBioengineering

M. A. Gravely

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Author profile →

6 papers

Recent·Most cited

Machine Learning Assisted Spectral Fingerprinting for Immune Cell Phenotyping

A. Nadeem, S. Lyons, A. Kindopp, A. Jamieson, D. Roxbury

This paper uses NIR fluorescence and Raman microscopy combined with machine learning to identify macrophage phenotypes based on DNA-SWCNT interactions, achieving >95% accuracy.

bioRxiv · Mar 5, 2024 · PreprintImmunology

Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles

P. V. Jena, M. A. Gravely, C. Cupo, M. M. Safaee, D. Roxbury, D. A. Heller

This paper introduces a hyperspectral counting method to accurately quantify nanomaterials in single cells and organelles, revealing significant heterogeneity in carbon nanotube uptake.

bioRxiv · Nov 24, 2021Bioengineering

Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells

M. A. Gravely, D. Roxbury

This study uses multispectral imaging to track the intracellular trafficking of DNA-SWCNTs in endothelial cells, revealing dynamic processes and aggregation patterns over time.

bioRxiv · Dec 14, 2020Bioengineering

A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress

M. M. Safaee, M. A. Gravely, D. Roxbury

This paper develops a wearable optical microfibrous biomaterial with encapsulated nanosensors for real-time, noninvasive monitoring of hydrogen peroxide levels in wounds.

bioRxiv · Jul 24, 2020Bioengineering

Oligonucleotide Length Determines Intracellular Stability of DNA-Wrapped Carbon Nanotubes

M. Gravely, M. M. Safaee, D. Roxbury

This study shows that oligonucleotide length affects the intracellular stability and fate of DNA-wrapped carbon nanotubes in mammalian cells.

bioRxiv · May 20, 2019 · PreprintBioengineering

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux

P. V. Jena, D. Roxbury, T. V. Galassi, L. Akkari, C. P. Horoszko, D. B. Iaea, J. Budhathoki-Uprety, N. H. Pipalia, A. S. Haka, J. D. Harvey, J. Mittal, F. R. Maxfield, J. A. Joyce, D. A. Heller

This paper develops an optical reporter using carbon nanotubes to measure endolysosomal lipid flux in live cells, revealing lipid accumulation in disease models and sub-cellular heterogeneity.

bioRxiv · Aug 28, 2017Bioengineering