Author

L. Akkari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Vegna· 2 shared A. Lozano· 1 shared A. Riviere· 1 shared A. S. Haka· 1 shared A. Zine El Aabidine· 1 shared C. F. Ramirez· 1 shared C. P. Horoszko· 1 shared C. Ramirez· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

S. Vegna

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

C. F. Ramirez, D. Taranto, M. Ando-Kuri, M. H. de Groot, E. Tsouri, Z. Huang, D. de Groot, R. J. Kluin, D. J. Kloosterman, J. Verheij, J. Xu, S. Vegna, L. Akkari

This study identifies how cancer genetics shape the tumor microenvironment in hepatocellular carcinoma, revealing myeloid cell-specific vulnerabilities that can be targeted with GM-CSF inhibition.

bioRxiv · Oct 29, 2023Cancer Biology

Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of primary and metastatic hepatocellular carcinoma

A. Lozano, F.-R. Souche, C. Ramirez, S. Vegna, G. Desandre, A. Riviere, V. Dardalhon, A. Zine El Aabidine, P. Fort, L. Akkari, U. Hibner, D. Gregoire

This study shows that varying levels of MAPK Erk signaling in Ras-transformed cells influence tumor growth and immune evasion in a mouse model of hepatocellular carcinoma.

bioRxiv · Aug 13, 2021Cancer Biology

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux

P. V. Jena, D. Roxbury, T. V. Galassi, L. Akkari, C. P. Horoszko, D. B. Iaea, J. Budhathoki-Uprety, N. H. Pipalia, A. S. Haka, J. D. Harvey, J. Mittal, F. R. Maxfield, J. A. Joyce, D. A. Heller

This paper develops an optical reporter using carbon nanotubes to measure endolysosomal lipid flux in live cells, revealing lipid accumulation in disease models and sub-cellular heterogeneity.

bioRxiv · Aug 28, 2017Bioengineering