Author

D. A. Heller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:imaging· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Roxbury· 2 shared P. V. Jena· 2 shared T. V. Galassi· 2 shared Z. Yaari· 2 shared A. Jagota· 1 shared A. Ogirala· 1 shared A. S. Haka· 1 shared A. Settle· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

D. Roxbury

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions

B. E. Mc Larney, M. Kim, S. Roberts, M. Skubal, H.-T. Hsu, A. Ogirala, N. PILLARSETTY, D. A. Heller, J. S. Lewis, J. Grimm

This study demonstrates that SWIR imaging with pHLIP ICG enables sensitive tumor detection and resection under ambient lighting conditions in a preclinical breast cancer model.

bioRxiv · Sep 7, 2022Cancer Biology

Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles

P. V. Jena, M. A. Gravely, C. Cupo, M. M. Safaee, D. Roxbury, D. A. Heller

This paper introduces a hyperspectral counting method to accurately quantify nanomaterials in single cells and organelles, revealing significant heterogeneity in carbon nanotube uptake.

bioRxiv · Nov 24, 2021Bioengineering

Machine-Perception Nanosensor Platform to Detect Cancer Biomarkers

Z. Yaari, Y. Yang, E. Apfelbaum, A. Settle, Q. Cullen, W. Cai, K. Long Roche, D. A. Levine, M. Fleisher, L. Ramanathan, M. Zheng, A. Jagota, D. A. Heller

This paper develops a machine-perception nanosensor platform using optical arrays and machine learning to detect cancer biomarkers in biofluids, achieving high F1-scores in uterine lavage samples.

bioRxiv · Apr 28, 2021 · PreprintBioengineering

Edaravone-Loaded Mesoscale Nanoparticles Treat Cisplatin-Induced Acute Kidney Injury

R. M. Williams, J. Shah, E. Mercer, H. S. Tian, J. M. Cheung, M. Dorso, E. A. Jaimes, D. A. Heller

This study develops edaravone-loaded mesoscale nanoparticles for treating cisplatin-induced acute kidney injury, showing improved renal function and reduced oxidative stress in mice.

bioRxiv · Jan 24, 2020 · PreprintBioengineering

Long-Term In Vivo Biocompatibility of Single-Walled Carbon Nanotubes

T. V. Galassi, M. Antman-Passig, Z. Yaari, J. Jessurun, R. E. Schwartz, D. A. Heller

This study evaluates the long-term biocompatibility and biodistribution of single-walled carbon nanotubes in mice after intravenous administration, finding low-level persistence and no adverse effects.

bioRxiv · Dec 9, 2019Bioengineering

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux

P. V. Jena, D. Roxbury, T. V. Galassi, L. Akkari, C. P. Horoszko, D. B. Iaea, J. Budhathoki-Uprety, N. H. Pipalia, A. S. Haka, J. D. Harvey, J. Mittal, F. R. Maxfield, J. A. Joyce, D. A. Heller

This paper develops an optical reporter using carbon nanotubes to measure endolysosomal lipid flux in live cells, revealing lipid accumulation in disease models and sub-cellular heterogeneity.

bioRxiv · Aug 28, 2017Bioengineering