Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance
K. Jiang, S. B. Lim, J. Xiao, D. S. Jokhun, M. Shang, X. Song, P. Zhang, L. Liang, B. C. Low, G. V. Shivashankar, C. T. Lim
The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.
bioRxiv · Jul 22, 2022Cancer Biology