Author

B. C. Low

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell signaling & trafficking· 5 Research Focus:development & morphogenesis· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2

Frequent Co-Authors

C. T. Lim· 3 shared J. Xiao· 3 shared D. C. P. Wong· 2 shared K. Jiang· 2 shared P. Kanchanawong· 2 shared P. Zhang· 2 shared S. B. Lim· 2 shared A. Bershadsky· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

C. T. Lim

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Coordination of focal adhesion nanostructure and mechano-signaling drives cardiomyocyte differentiation

J. Xiao, X. Zhong, J. W. Ang, D. C. P. Wong, C. J. M. Lee, R. S.-Y. Foo, P. Kanchanawong, B. C. Low

This study identifies BNIP-2 as a key organizer of focal adhesion nanostructure that enhances signaling and traction force, essential for cardiomyocyte differentiation.

bioRxiv · Nov 13, 2023 · PreprintCell Biology

Multiscale mechanisms driving tissue rupture by invading cells

S. K. Wu, F. Sun, C. Z. Ho, Y. Lou, C. B.-X. Huang, M. H. Nai, J. Xiao, M. Shagirov, J. F. L. Chin, D. Lim, S. Verma, D. S. Tan, P. Marcq, A. Yap, C. T. Lim, , B. C. Low

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

bioRxiv · Sep 25, 2023Cell Biology

Focal adhesions are controlled by microtubules through local contractility regulation

J. Aureille, S. Barnett, I. Arnal, L. Lafanechere, B. C. Low, P. Kanchanawong, A. Mogilner, A. Bershadsky

This study shows microtubules control focal adhesion disassembly via KANK1-mediated local contractility regulation involving RhoA/ROCK and other proteins.

bioRxiv · Apr 17, 2023Cell Biology

Natural Killer cell contractility and cytotoxicity is driven by TLR3 agonist-mediated TAZ cytoplasmic sequestration

D. C. P. Wong, Z. Xia, N. Shao, J. Y. Yeo, T. Thivakar, I. Yow, A. M. Salazar, Y.-C. Liou, B. C. Low, J. L. Ding

This study shows that TLR3 agonist hiltonol sequesters TAZ in NK cells, enhancing cytotoxicity by increasing contractility and reducing inhibitory receptors.

bioRxiv · Jan 18, 2023 · PreprintCell Biology

Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance

K. Jiang, S. B. Lim, J. Xiao, D. S. Jokhun, M. Shang, X. Song, P. Zhang, L. Liang, B. C. Low, G. V. Shivashankar, C. T. Lim

The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.

bioRxiv · Jul 22, 2022Cancer Biology

Cancer exosomes harbor diverse hypoxia-targeted mRNAs and contribute toward tumor angiogenesis

P. Zhang, S. B. Lim, K. Jiang, T. W. Chew, B. C. Low, C. T. Lim

This study identifies hypoxia-targeted mRNAs in cancer exosomes that promote angiogenesis and reprogram recipient cells.

bioRxiv · Jun 12, 2020 · PreprintCancer Biology

Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel

K. Gupta, I. C. Ng, B. P. Nguyen, L. Tucker-Kellogg, B. C. Low, H. Yu

The paper shows bile canaliculi contract by releasing calcium into hepatocytes via mechanosensitive channels, driven by bile pressure and regulated by Piezo-1.

bioRxiv · Oct 22, 2018Cell Biology