C. T. Lim

Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function

The paper shows that CDK regulation influences MCM helicase loading at yeast origins, revealing how cell cycle control has shaped origin structure and function.

Gel-Shrink Softlithography: Enabling 3D Tissue Culture Microstructure Miniaturization and Tacky Super-Soft Material Molding

This paper introduces a hydrogel soft lithography technique that reduces microfeature dimensions by 2-fold and enables molding of super-soft materials, revealing curvature-dependent cell alignment patterns.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance

The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.

Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

The paper shows that surface curvature and basal hydraulic stress influence spatial patterns of cell extrusion in epithelial monolayers.

Biomimetic Vasculatures by 3D-Printed Porous Molds

This paper introduces a 3D-printed porous mold technique to create cell-laden, perfusable vascular models that mimic biological and anatomical features of blood vessels.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease

This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease

This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.

Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase

This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.

Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion

This study identifies a dual-mode actin mechanism involving lamellipodia protrusions and purse-string contractility that drives apoptotic cell extrusion in epithelia.

Cancer exosomes harbor diverse hypoxia-targeted mRNAs and contribute toward tumor angiogenesis

This study identifies hypoxia-targeted mRNAs in cancer exosomes that promote angiogenesis and reprogram recipient cells.

Endosomal spatio-temporal modulation of the cortical RhoA zone conditions epithelial cell organization

This study shows EpCAM regulates RhoA trafficking via endosomes to control actomyosin dynamics, cell shape, and polarity in epithelial cells.

Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration

This study shows that collective cell migration in epithelial monolayers arises from single-cell polarity signals rather than cell-cell junctions.

Reticulocyte Infection Leads to Altered Behaviour, Drug Sensitivity and Host Cell Remodelling by Plasmodium falciparum.

This paper shows that Plasmodium falciparum infects reticulocytes with higher affinity, alters drug sensitivity, and remodels host cells through transcriptomic changes.

Mechanical Stretch Kills Transformed Cancer Cells

The paper shows that cyclic mechanical stretch induces apoptosis in transformed cancer cells but promotes growth in normal cells, with mechanoptosis driven by calcium influx and calpain activation.