S. Ramalingam

SmERF6 promotes the expression of terpenoid pathway in Salvia officinalis and improves the production of high value abietane diterpenes, carnosol and carnosic acid

This study overexpresses SmERF6 in Salvia officinalis to enhance the production of diterpenes like carnosol and carnosic acid, showing significant increases in their levels.

Development of an efficient single-cell cloning and expansion strategy for genome edited induced pluripotent stem cells

This paper develops an efficient single-cell cloning and expansion strategy for genome-edited hiPSCs, improving viability and expansion while maintaining pluripotency.

The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation

This study shows that altering CMPK2 expression disrupts macrophage mitochondrial function and dysregulates basal inflammation.

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

Exosomes isolated from two different cell lines using three different isolation techniques show variation in physical and molecular characteristics

This study compares three exosome isolation techniques from cancer cell lines, finding variations in yield, purity, and molecular characteristics.

Role of RBC membrane protein palmitoylation in regulation of molecular topology and susceptibility to Plasmodium falciparum invasion

The paper investigates how palmitoylation affects RBC membrane proteins and their role in Plasmodium falciparum invasion, finding that palmitoylation regulates receptor expression and susceptibility.

The Novel Mnk1/2 Degrader VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis

This study identifies VNLG-152R, a Mnk1/2 degrader, as a potent inhibitor of TNBC tumor growth and metastasis with minimal toxicity.

Evidence for hyper-reductive redox in a subset of heart failure patients

The paper identifies a subset of heart failure patients with hyper-reductive redox status, suggesting RS may contribute to HF pathogenesis and supports redox stratification for personalized therapy.