D. Skurnik

Pre-clinical in vitro and in vivo characterization of a maternal vaccination before conception to protect against severe neonatal infections caused by Escherichia coli K1

This study evaluates a maternal vaccine against E. coli K1 in mice, showing it protects newborns from severe infections.

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: a new approach to prevent and treat bacterial infections

This paper develops an antibody-drug conjugate targeting Pseudomonas aeruginosa that kills bacteria with minimal mammalian cell toxicity and synergizes with antibiotics.

The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier

This study identifies HP1γ as an epigenetic repressor of IFN-γ responsive genes at the gut epithelial barrier, showing its role in dampening immune responses.

A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates

This study uses TnSeq to identify E. coli K1 genes important for meningitis, focusing on PNAG as a vaccine target, showing its efficacy against E. coli and Group B Streptococcus in neonatal models.

The human-specific miR-6762-5p is an activator of RhoA GTPase enhancing Shigella flexneri intercellular spreading

This study identifies miR-6762-5p as a human-specific microRNA that activates RhoA to enhance Shigella intercellular spreading.

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

The study shows that aminoglycosides can induce the SOS response in E. coli via a qnrD-plasmid, leading to qnrD transcription through NO accumulation driven by plasmid-encoded genes.