Author

D. Sosa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Assay:bulk RNA-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:Drosophila· 2 Approach:experimental assay· 2

Frequent Co-Authors

M. Long· 5 shared S. Xia· 5 shared D. Arsala· 4 shared J. Chen· 4 shared A. Guzzetta· 2 shared C. Dong· 2 shared L. Zhang· 2 shared A. R. Osorio· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersEvolutionary Biology

M. Long

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Author profile →

6 papers

Recent·Most cited

Prediction of myeloid malignant cells in Fanconi anemia using machine learning

L. A. Flores-Mejia, P. Siliceo-Portugal, I. Garcia-Quezada, U. J. Figueroa, B. T. B. Martinez, D. Sosa, A. R. Osorio, H. Tovar, S. Frias, A. Rodriguez

This study uses machine learning to identify myeloid malignant transcriptional profiles in FA patients' bone marrow using scRNAseq data, achieving high sensitivity and specificity for MDS and AML detection.

bioRxiv · Dec 31, 2023Cancer Biology

One million years of solitude: the rapid evolution of de novo protein structure and complex

J. Chen, Q. Li, S. Xia, D. Arsala, D. Sosa, D. Wang, M. Long

This study examines the rapid structural evolution of de novo genes in rice over 1 million years, finding faster changes in disordered regions and structured elements compared to gene duplicates.

bioRxiv · Dec 24, 2023Evolutionary Biology

Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.

J. Chen, P. Landback, D. Arsala, A. Guzzetta, S. Xia, J. Atlas, D. Sosa, Y. Zhang, J. Cheng, B. Shen, M. Long

This study identifies evolutionarily new genes in humans with disease phenotypes, showing their enrichment in male reproductive diseases and adaptive traits like brain size and color vision.

bioRxiv · Nov 14, 2023Evolutionary Biology

New gene evolution with subcellular expression patterns detected in PacBio-sequenced genomes of Drosophila genus

C. Dong, L. Zhang, S. Xia, D. Sosa, D. Arsala, M. Long

The paper analyzes gene age and subcellular expression patterns in Drosophila species using PacBio sequencing, finding new genes enriched in extracellular compartments and old genes in mitochondria and plasma membrane.

bioRxiv · Nov 30, 2022 · PreprintEvolutionary Biology

The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

U. Lee, D. Arsala, S. Xia, C. Li, M. Ali, N. Svetec, C. Langer, D. Sobreira, I. Eres, D. Sosa, J. Chen, L. Zhang, P. Reilly, A. Guzzetta, J. J. Emerson, , M. Long

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

bioRxiv · Nov 30, 2022 · PreprintEvolutionary Biology

Species-specific gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection

Y. Huang, J. Chen, C. Dong, D. Sosa, S. Xia, Y. Ouyang, C. Fan, D. Li, E. Mortola, M. Long, J. Bergelson

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.

bioRxiv · Apr 5, 2021Evolutionary Biology