Y. Ouyang

Combining Bulk and Single-Cell RNA Sequencing Data to Identify RNA methylation and Autophagy-Related Signatures in Patients with Chronic Obstructive Pulmonary Disease

The paper identifies RNA methylation and autophagy-related genes in COPD using bulk and single-cell RNA sequencing data and validates them in animal models.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

Phosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

Gli1+ mesenchymal progenitors contribute to multilineage differentiation in a mouse model of post-traumatic joint injury

This study establishes a mouse model of post-traumatic joint injury and identifies Gli1+ mesenchymal progenitors as key contributors to arthrofibrosis and heterotopic ossification.

G6PD Inhibition Sensitizes Ovarian Cancer Cells to Oxidative Stress in the Metastatic Omental Microenvironment

This study shows G6PD inhibition increases oxidative stress and reduces omental metastases in ovarian cancer.

Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway

This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.

Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

Untargeted 1H NMR Metabolomics and Pathway Analysis Reveals Dysregulated Proteostasis in Cyclophilin D (CypD)-deficient Mice Tissues

This study uses metabolomics to show that CypD deficiency disrupts protein homeostasis and metabolic pathways in multiple tissues of mice.

Species-specific gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.

Network-aware reaction pattern recognition reveals regulatory signatures of mitochondrial dysfunction

The paper introduces Metaboverse, a tool for network-aware reaction pattern recognition in metabolic data, identifying regulatory signatures of mitochondrial dysfunction in lung adenocarcinoma and respiratory deficiency models.

Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

Negative effects characterization and comparative transcriptomics elucidation on the lag phase of an industrial S. cerevisiae under the corn stover hydrolysate stress

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.

H. pylori infection inhibits autophagy to aggravate DNA damage by p62-mediated Rad51 ubiquitination

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.