Author

D. Southworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

E. Tse· 2 shared A. Frost· 1 shared A. Sutter· 1 shared C. M. Azumaya· 1 shared D. A. Agard· 1 shared J. A. Lauer· 1 shared J. Lempart· 1 shared K. A. Verba· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

E. Tse

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Author profile →

2 papers

Recent·Most cited

Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM

M. Sun, C. M. Azumaya, E. Tse, A. Frost, D. Southworth, K. A. Verba, Y. Cheng, D. A. Agard

This study optimizes K3 camera settings in CDS mode for cryo-EM, showing improved resolution and throughput for protein complex imaging.

bioRxiv · Nov 8, 2020Biophysics

Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity

J. Lempart, E. Tse, J. A. Lauer, M. I. Ivanova, A. Sutter, N. Yoo, P. Huettemann, D. Southworth, U. Jakob

This study investigates how polyphosphate (polyP) affects α-synuclein fibril formation and cytotoxicity, finding that polyP alters fibril morphology and reduces membrane interaction, suggesting potential therapeutic applications.

bioRxiv · Jul 16, 2019Cell Biology