A subset of CB002 xanthine analogues bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
L. Hernandez Borrero, D. T. Dicker, J. Santiago, J. Sanders, X. Tian, N. Ahsan, A. Lev, L. Zhou, W. S. El-Deiry
The paper identifies CB002 analogues that restore p53 signaling and target an S-phase checkpoint in p53-mutated tumors, inducing apoptosis and reducing proliferation without harming normal cells.
eLife · Jul 29, 2021Peer-reviewedCancer Biology