N. Ahsan

Back from the dead: the atypical kinase activity of a pseudokinase regulator of cation fluxes during inducible immunity

This study identifies ILK1, a plant pseudokinase with kinase activity, and shows it interacts with multiple proteins involved in immunity and cation-dependent signaling.

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

This study shows DDX4, a germline factor, enhances chemoresistance and motility in SCLC cells by altering metabolism and EMT-like features.

The mitogen-activated protein kinase kinase kinase, ILK5, regulates plant purinergic receptor-mediated, innate immunity

This study identifies ILK5 as a downstream substrate of P2K1 kinase that mediates MAPK cascade activation in Arabidopsis, enhancing innate immunity through phosphorylation of MPK3/6.

A subset of CB002 xanthine analogues bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

The paper identifies CB002 analogues that restore p53 signaling and target an S-phase checkpoint in p53-mutated tumors, inducing apoptosis and reducing proliferation without harming normal cells.

Scaffold Protein RACK1 inhibitor compounds prevent the Focal Adhesion Kinase mediated breast cancer cell migration and invasion potential

The paper shows RACK1 inhibitors reduce breast cancer cell migration and invasion by blocking FAK activation, suggesting a potential therapeutic strategy for preventing metastasis.

Loss of ClpP Function in Clostridioides difficile 630 Significantly Impacts Sporulation Systems

This study shows that loss of ClpP function in C. difficile 630 reduces sporulation and cytotoxicity, suggesting ClpP as a potential anti-sporulation target.

P53-independent restoration of p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9

PG3-Oc restores p53 pathway signaling in mutant-p53 tumors through ATF4 modulation by ERK1/2 and CDK9, inducing p53 effector genes for cell death and tumor suppression.

S-Acylation of plant immune receptors mediates immune signaling in plasma membrane nanodomains

This study shows that S-acylation of plant immune receptors by PAT5 and PAT9 regulates their localization and signaling in plasma membrane nanodomains, affecting immune responses.