Author

D. T. Fearon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. Yan· 3 shared A. Pommier· 2 shared M. Egeblad· 2 shared A. Eberhardt· 1 shared A. Gouronnec· 1 shared A. S. Almeida· 1 shared C. A. Iacobuzio-Donahue· 1 shared C. O. dos Santos· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

R. Yan

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Author profile →

4 papers

Recent·Most cited

T cell-mediated development of stromal fibroblasts with an immune-enhancing chemokine profile

R. Yan, D. T. Fearon

The paper shows that stromal fibroblasts can switch from an immune-suppressive to an immune-activating chemokine profile in response to T cell-derived cytokines.

bioRxiv · Apr 3, 2022Immunology

Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy

Z. Wang, R. Yan, J. Li, Y. Gao, P. Moresco, M. Yao, J. F. Hechtman, M. J. Weiss, T. Janowitz, D. T. Fearon

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

bioRxiv · Sep 4, 2020 · PreprintImmunology

Cancer cell CCR2 orchestrates suppression of the adaptive immune response

M. R. Fein, X. Y. He, A. S. Almeida, E. Bruzas, A. Pommier, R. Yan, A. Eberhardt, D. T. Fearon, L. Van Aelst, J. E. Wilkinson, C. O. dos Santos, M. Egeblad

This study shows that CCR2 in cancer cells suppresses immune response by reducing CD103+ dendritic cell recruitment and altering immune cell infiltration and activation.

bioRxiv · Dec 27, 2019Cancer Biology

Endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

A. Pommier, N. Anaparthy, N. Memos, Z. Larkin Kelley, A. Gouronnec, J. Albrengues, M. Egeblad, C. A. Iacobuzio-Donahue, S. K. Lyons, D. T. Fearon

The paper shows that endoplasmic reticulum stress enables pancreatic cancer cells to evade immune detection and form latent metastases.

bioRxiv · Sep 11, 2017Immunology