Author

M. J. Weiss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

A. F. Alpi· 1 shared A. Gross· 1 shared A. Islam· 1 shared A. K. Best· 1 shared A. M. Ali· 1 shared A. S. Keller· 1 shared A. S. Padilha· 1 shared B. E. Isakson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCell Biology

A. F. Alpi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multiplex Base Editing to Protect from CD33-Directed Therapy: Implications for Immune and Gene Therapy

F. Borot, O. Humbert, G. A. Newby, E. Fields, S. Kohli, S. Radtke, G. S. Laszlo, T. Mayuranathan, A. M. Ali, M. J. Weiss, J. S. Yen, R. B. Walter, D. R. Liu, S. Mukherjee, H.-P. Kiem

The paper develops a base editing approach to reduce on-target toxicity in CD33-directed therapies by editing CD33 and gamma globin genes in hematopoietic stem and progenitor cells.

bioRxiv · Feb 23, 2023 · PreprintCell Biology

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

D. Sherpa, J. Mueller, O. Karayel, J. Chrustowicz, P. Xu, K. V. Gottemukkala, C. Baumann, A. Gross, O. Czarnezki, W. Zhang, J. Gu, J. Nilvebrant, M. J. Weiss, S. Sidhu, P. J. Murray, , A. F. Alpi

The paper identifies UBE2H-CTLH ubiquitylation modules that regulate stages of human erythropoiesis, showing their role in controlling maturation and heme synthesis.

bioRxiv · Jan 18, 2022 · PreprintCell Biology

The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

S. A. Polyanskaya, R. Y. Moreno, B. Lu, R. Feng, Y. Yao, S. Irani, O. Klingbeil, Z. Yang, Y. Wei, O. E. Demerdash, L. A. Benjamin, M. J. Weiss, Y. Zhang, C. R. Vakoc

This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.

bioRxiv · May 9, 2021Cancer Biology

Endothelial alpha globin is a nitrite reductase

T. C. S. Keller, A. S. Keller, G. B. Broseghini-Filho, J. T. Butcher, H. R. Askew Page, A. Islam, Z. Y. Tan, L. J. DeLalio, C. Lechauve, S. D. Brooks, P. Sharma, K. Hong, W. Xu, A. S. Padilha, C. A. Ruddiman, , B. E. Isakson

This study shows endothelial alpha globin functions as a nitrite reductase to mediate hypoxia-induced vasodilation in resistance arteries.

bioRxiv · Feb 12, 2021Physiology

Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy

Z. Wang, R. Yan, J. Li, Y. Gao, P. Moresco, M. Yao, J. F. Hechtman, M. J. Weiss, T. Janowitz, D. T. Fearon

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

bioRxiv · Sep 4, 2020 · PreprintImmunology