Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy
Z. Wang, R. Yan, J. Li, Y. Gao, P. Moresco, M. Yao, J. F. Hechtman, M. J. Weiss, T. Janowitz, D. T. Fearon
The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.
bioRxiv · Sep 4, 2020 · PreprintImmunology