Author

D. Thacker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:C. elegans· 1

Frequent Co-Authors

B. Rowlinson· 1 shared D. J. Brockwell· 1 shared E. Axell· 1 shared G. N. Khan· 1 shared G. Sneideriene· 1 shared H. Greer· 1 shared J. A. Crossley· 1 shared J. M. Machin· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiophysics

B. Rowlinson

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3 papers

Recent·Most cited

Heterogeneous primary nucleation determines Aβ42 fibrilstructure.

E. Axell, S. Linse, D. Thacker

This study shows that heterogeneous primary nucleation at surfaces determines the fibril structure of Aβ42, with different structures formed in identical solutions depending on the surface type.

bioRxiv · Nov 2, 2026 · PreprintBiochemistry

Residues 2-7 of alpha-synuclein regulate amyloid formation via lipid-dependent and -independent pathways

K. M. Dewison, B. Rowlinson, J. M. Machin, J. A. Crossley, D. Thacker, M. Wilkinson, S. E. Ulamec, G. N. Khan, N. A. Ranson, P. van-Oosten Hawle, D. J. Brockwell, S. Radford

This study identifies residues 2-7 of alpha-synuclein as regulators of amyloid formation, showing they slow fibril formation and reduce aggregation in vitro and in vivo without affecting membrane binding.

bioRxiv · May 24, 2024 · PreprintBiophysics

A Kinetic Map of the Influence of Biomimetic Lipid Membrane Models on Aβ42 Aggregation

K. N. Baumann, M. Sanguanini, O. Rimon, G. Sneideriene, H. Greer, D. Thacker, M. M. Schneider, S. Linse, T. P. J. Knowles, M. Vendruscolo

This study investigates how different lipid membrane models affect Aβ42 aggregation kinetics in vitro, showing inhibition by ER and Golgi membranes.

ACS Chemical Neuroscience · Dec 27, 2022Peer-reviewedBiophysics