M. Wilkinson

Residues 2-7 of alpha-synuclein regulate amyloid formation via lipid-dependent and -independent pathways

This study identifies residues 2-7 of alpha-synuclein as regulators of amyloid formation, showing they slow fibril formation and reduce aggregation in vitro and in vivo without affecting membrane binding.

Phenology across scales: an intercontinental analysis of leaf-out dates in temperate deciduous tree communities

The paper analyzes leaf-out variability across temperate deciduous forests in North America and Europe, finding similar intra-community variability despite differences in species richness and environmental conditions.

Tau amyloid polymorphism is shaped by local structural propensities of its protein sequence

The paper identifies a C-terminal tau peptide that adopts polymorphic conformations contributing to disease-specific tau filament folds and propagation.

Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

The paper presents structural and biochemical analysis of two phage proteins that inhibit or co-opt the bacterial RecBCD complex to evade host immunity.

Caecilian genomes reveal molecular basis of adaptation and convergent evolution of limblessness in snakes and caecilians.

The paper analyzes caecilian genomes to identify molecular mechanisms underlying limblessness and convergent evolution with snakes, finding shared genetic targets involved in limb development.

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

The paper examines antibody responses to HCoV-OC43 and SARS-CoV-2 in children with autoimmune rheumatic diseases, finding stronger spike antibody responses and cross-reactivity despite immunosuppressive treatment.

Selective labelling of arginine residues engaged in binding sulfatedglycosaminoglycans

This paper introduces a method to identify arginine residues in proteins that bind sulfated glycosaminoglycans by selectively labeling them using chemical reagents and mass spectrometry analysis.

Terasaki Spiral Ramps and Intracellular Diffusion

This study analyzes diffusion on a surface with Terasaki ramps and finds they enhance the transport of water-soluble molecules in the ER lumen.

Influenza C incidence and herd immunity in Lancaster, UK, in the winter of 2014-2015

The paper estimates seropositivity and assesses influenza C incidence in Lancaster, UK, finding high herd immunity but limited active infection.