Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers
S. V. Krasik, E. A. Bryushkova, G. V. Sharonov, D. S. Myalik, E. V. Shurganova, D. V. Komarov, I. A. Shagina, P. S. Shpudeiko, M. A. Turchaninova, M. T. Vakhitova, I. V. Samoylenko, D. T. Marinov, L. V. Demidov, V. E. Zagainov, D. M. Chudakov, E. O. Serebrovskaya
This study evaluates BCR repertoires in tumors, draining lymph nodes, and blood of cancer patients, revealing differences in clonotype expansion, hypermutation, and CDR-H3 properties.
bioRxiv · Apr 16, 2023Immunology