Author

E. A. Shirshin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. E. Nikonova· 2 shared M. V. Shirmanova· 2 shared N. I. Ignatova· 2 shared A. B. Rubin· 1 shared A. D. Komarova· 1 shared A. M. Mozherov· 1 shared A. V. Gayer· 1 shared A. V. Stepanov· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

E. E. Nikonova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Metabolic heterogeneity of colorectal cancer as a prognostic factor: insights gained from fluorescence lifetime imaging

A. D. Komarova, S. D. Sinyushkina, I. D. Shchechkin, I. N. Druzhkova, S. A. Smirnova, V. M. Terekhov, A. M. Mozherov, N. I. Ignatova, E. E. Nikonova, E. A. Shirshin, L. E. Shimolina, S. V. Gamayunov, V. I. Shcheslavskiy, M. V. Shirmanova

This study uses fluorescence lifetime imaging to quantify metabolic heterogeneity in colorectal cancer, finding higher heterogeneity in patient tumors compared to cell lines and xenografts, with potential prognostic value.

bioRxiv · Jan 2, 2024Cancer Biology

Label-free sensing of cells with fluorescence lifetime imaging: the quest for metabolic heterogeneity

E. A. Shirshin, M. V. Shirmanova, A. V. Gayer, M. M. Lukina, E. E. Nikonova, B. P. Yakimov, G. S. Budylin, V. V. Dudenkova, N. I. Ignatova, D. V. Komarov, V. V. Yakovlev, W. Becker, E. V. Zagaynova, V. V. Shcheslavskiy, M. O. Scully

This study demonstrates a novel FLIM data analysis approach to better detect metabolic heterogeneity in cancer cells, validated through chemotherapy-treated cell imaging.

bioRxiv · Jan 12, 2022Cancer Biology

Label-free imaging of macrophage phenotypes and phagocytic activity in the human dermis in vivo using two-photon excited FLIM

M. Kröger, J. Scheffel, E. A. Shirshin, J. Schleusener, M. C. Meinke, J. Lademann, M. Maurer, M. Darvin

This paper uses TPE-FLIM to visualize and classify macrophage phenotypes and phagocytic activity in human skin in vivo, with machine learning achieving high sensitivity and specificity.

bioRxiv · Nov 29, 2021 · PreprintBiophysics

The photocycle of orange carotenoid protein conceals distinct intermediates and asynchronous changes in the carotenoid and protein components

E. G. Maksimov, N. N. Sluchanko, Y. B. Slonimskiy, A. V. Stepanov, E. A. Shirshin, G. V. Tsoraev, K. E. Klementiev, O. V. Slatinskaya, E. P. Lukashev, T. Friedrich, V. Z. Paschenko, A. B. Rubin

This study identifies two novel photocycle intermediates in the Orange Carotenoid Protein (OCP) using time-resolved spectroscopy, revealing asynchronous changes in carotenoid and protein components.

bioRxiv · Jul 23, 2017Biophysics